Tetrahydrofuran → tert-butyl N-[2-(3,5-difluorophenyl)-1-oxopropan-2-yl]carbamate

HRID 2149202Notes

Reaction equation

HRID 2149202 reaction equation
[Al+3:27].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C:9]([C:10](=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])([CH3:17])[c:18]1[cH:19][c:20]([F:25])[cH:21][c:22]([F:24])[cH:23]1.[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[H-:26].[H-:29].[H-:30].[H-:31].[Li+:28]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[NH:8][C:9]([CH:10]=[O:11])([CH3:17])[c:18]1[cH:19][c:20]([F:25])[cH:21][c:22]([F:24])[cH:23]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 66865158tert-Butyl 2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propanoate

Product 1

HCID 86616399tert-butyl N-[2-(3,5-difluorophenyl)-1-oxopropan-2-yl]carbamate

Sources & evidence

ORD record
ord-9d66366c48564f33aefec2ed8abd5132
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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