Acetic Acid → N-(3-Fluoro-4-(7-hydroxy-6-methoxyquinolin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

HRID 2149504Notes

Reaction equation

HRID 2149504 reaction equation
[BrH:53].[C:54]([OH:55])(=[O:56])[CH3:57].[CH2:8]([c:9]1[cH:10][cH:11][cH:12][cH:13][cH:14]1)[O:15][c:16]1[c:17]([O:51][CH3:52])[cH:18][c:19]2[c:20]([O:26][c:27]3[c:28]([F:50])[cH:29][c:30]([NH:33][C:34](=[O:35])[c:36]4[c:37](=[O:49])[n:38](-[c:42]5[cH:43][cH:44][c:45]([F:48])[cH:46][cH:47]5)[cH:39][cH:40][cH:41]4)[cH:31][cH:32]3)[cH:21][cH:22][n:23][c:24]2[cH:25]1.[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7]>>[OH:15][c:16]1[c:17]([O:51][CH3:52])[cH:18][c:19]2[c:20]([O:26][c:27]3[c:28]([F:50])[cH:29][c:30]([NH:33][C:34](=[O:35])[c:36]4[c:37](=[O:49])[n:38](-[c:42]5[cH:43][cH:44][c:45]([F:48])[cH:46][cH:47]5)[cH:39][cH:40][cH:41]4)[cH:31][cH:32]3)[cH:21][cH:22][n:23][c:24]2[cH:25]1

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 260Hydrogen BromideHCID 6422Trifluoroacetic acidHCID 58833040N-(4-(7-(Benzyloxy)-6-methoxyquinolin-4-yloxy)-3-fluorophenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Product 1

HCID 135446414N-(3-Fluoro-4-(7-hydroxy-6-methoxyquinolin-4-yloxy)phenyl)-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

Sources & evidence

ORD record
ord-d750a83095b94a0584bf8fa2101df1df
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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