Hydrochloric Acid → [2-Isobutoxymethyl-7-(3-trifluoromethyl-pyridin-2-yl)-pyrido[2,3-d]pyrimidin-4-yl]-(5-trifluoromethyl-pyridin-2-yl)-amine
Reaction equation
[C:40](=[O:41])([O-:42])[O-:43].[Cl:1][c:2]1[c:3]2[c:4]([n:5][c:6]([CH2:8][O:9][CH2:10][CH:11]([CH3:12])[CH3:13])[n:7]1)[n:14][c:15](-[c:18]1[n:19][cH:20][cH:21][cH:22][c:23]1[C:24]([F:25])([F:26])[F:27])[cH:16][cH:17]2.[ClH:28].[Cs+:44].[Cs+:45].[NH2:29][c:30]1[n:31][cH:32][c:33]([C:36]([F:37])([F:38])[F:39])[cH:34][cH:35]1.[O:46]1[CH2:47][CH2:48][O:49][CH2:50][CH2:51]1.[O:54]=[C:55]([CH:56]=[CH:57][c:58]1[cH:59][cH:60][cH:61][cH:62][cH:63]1)[CH:64]=[CH:65][c:66]1[cH:67][cH:68][cH:69][cH:70][cH:71]1.[O:72]=[C:73]([CH:74]=[CH:75][c:76]1[cH:77][cH:78][cH:79][cH:80][cH:81]1)[CH:82]=[CH:83][c:84]1[cH:85][cH:86][cH:87][cH:88][cH:89]1.[O:90]=[C:91]([CH:92]=[CH:93][c:94]1[cH:95][cH:96][cH:97][cH:98][cH:99]1)[CH:100]=[CH:101][c:102]1[cH:103][cH:104][cH:105][cH:106][cH:107]1.[Pd:52].[Pd:53]>>[c:2]1([NH:29][c:30]2[n:31][cH:32][c:33]([C:36]([F:37])([F:38])[F:39])[cH:34][cH:35]2)[c:3]2[c:4]([n:5][c:6]([CH2:8][O:9][CH2:10][CH:11]([CH3:12])[CH3:13])[n:7]1)[n:14][c:15](-[c:18]1[n:19][cH:20][cH:21][cH:22][c:23]1[C:24]([F:25])([F:26])[F:27])[cH:16][cH:17]2Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-f4df9e5bc5b4453f8d45564171d3758e
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
Loading…