Acetyl chloride → N-[5-(8-acetyl-1-thia-3,8-diazaspiro[4.5]deca-2-en-2-yl)-2-methyl-4H-thieno[3,2-b]pyrrol-3-yl]-N-methylthiophene-2-sulfonamide

HRID 2151366Notes

Reaction equation

HRID 2151366 reaction equation
[CH3:1][N:2]([S:3](=[O:4])(=[O:5])[c:6]1[s:7][cH:8][cH:9][cH:10]1)[c:11]1[c:12]([CH3:29])[s:13][c:14]2[c:15]1[nH:16][c:17]([C:19]1=[N:23][CH2:22][C:21]3([S:20]1)[CH2:24][CH2:25][NH:26][CH2:27][CH2:28]3)[cH:18]2.[CH3:30][CH2:31][N:32]([CH2:33][CH3:34])[CH2:35][CH3:36].[CH3:37][C:38]([Cl:39])=[O:40].[O:41]1[CH2:42][CH2:43][CH2:44][CH2:45]1>>[CH3:1][N:2]([S:3](=[O:4])(=[O:5])[c:6]1[s:7][cH:8][cH:9][cH:10]1)[c:11]1[c:12]([CH3:29])[s:13][c:14]2[c:15]1[nH:16][c:17]([C:19]1=[N:23][CH2:22][C:21]3([S:20]1)[CH2:24][CH2:25][N:26]([C:38]([CH3:37])=[O:40])[CH2:27][CH2:28]3)[cH:18]2

Participants

5

Reactant 4

HCID 6367Acetyl chlorideHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 59411372N-methyl-N-[2-methyl-5-(1-thia-3,8-diazaspiro[4.5]deca-2-en-2-yl)-4H-thieno[3,2-b]pyrrol-3-yl]thiophene-2-sulfonamide

Product 1

HCID 24880660N-[5-(8-acetyl-1-thia-3,8-diazaspiro[4.5]deca-2-en-2-yl)-2-methyl-4H-thieno[3,2-b]pyrrol-3-yl]-N-methylthiophene-2-sulfonamide

Sources & evidence

ORD record
ord-76f7ee7a32624547bd92d83243dd68a5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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