Tetrahydrofuran → Diethyl 4-bromophenylmalonate

HRID 2152084Notes

Reaction equation

HRID 2152084 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([CH2:8][C:9](=[O:10])[O:11][CH2:12][CH3:13])[cH:6][cH:7]1.[C:22](#[N:23])[C:24](=[O:25])[O:26][CH2:27][CH3:28].[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[CH:14]([N-:15][CH:16]([CH3:17])[CH3:18])([CH3:19])[CH3:20].[Li+:21]>>[Br:1][c:2]1[cH:3][cH:4][c:5]([CH:8]([C:9](=[O:10])[O:11][CH2:12][CH3:13])[C:24](=[O:25])[O:26][CH2:27][CH3:28])[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 69336Ethyl cyanoformateHCID 5062348DiisopropylamideHCID 7020609Ethyl 2-(4-bromophenyl)acetate

Product 1

HCID 10519382Diethyl 4-bromophenylmalonate

Sources & evidence

ORD record
ord-c7adc9500bce480aa222a25568b183be
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

Loading…