Tetrahydrofuran → 3-Amino-5-chloro-N-cyclopropyl-6-(3-hydroxypropoxy)-4-methylthieno[2,3-b]pyridine-2-carboxamide
Reaction equation
[CH2:1]([CH2:2][CH2:3][OH:4])[OH:5].[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH3:6][Si:7]([N-:8][Si:9]([CH3:10])([CH3:11])[CH3:12])([CH3:13])[CH3:14].[CH:16]1([NH:19][C:20](=[O:21])[c:22]2[c:23]([NH2:36])[c:24]3[c:25]([n:26][c:27]([S:32]([CH3:33])=[O:34])[c:28]([Cl:31])[c:29]3[CH3:30])[s:35]2)[CH2:17][CH2:18]1.[Li+:15]>>[CH2:1]([CH2:2][CH2:3][O:4][c:27]1[n:26][c:25]2[c:24]([c:23]([NH2:36])[c:22]([C:20]([NH:19][CH:16]3[CH2:17][CH2:18]3)=[O:21])[s:35]2)[c:29]([CH3:30])[c:28]1[Cl:31])[OH:5]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-15301803dde44f7fbd9b3c366d4c6374
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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