Hydrochloric Acid → Methyl 6-amino-3-methoxy-2-pyrazinecarboxylate
Reaction equation
[Br:1][c:2]1[cH:3][n:4][c:5]([O:12][CH3:13])[c:6]([C:8](=[O:9])[O:10][CH3:11])[n:7]1.[C:14]([c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1)([c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1)=[NH:27].[CH3:28][C:29]([CH3:30])([O-:31])[CH3:32].[CH3:37][c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1.[CH:106]([Cl:107])([Cl:108])[Cl:109].[ClH:34].[Na+:33].[Na+:36].[O:44]1[CH2:45][CH2:46][CH2:47][CH2:48]1.[O:51]=[C:52]([CH:53]=[CH:54][c:55]1[cH:56][cH:57][cH:58][cH:59][cH:60]1)[CH:61]=[CH:62][c:63]1[cH:64][cH:65][cH:66][cH:67][cH:68]1.[O:69]=[C:70]([CH:71]=[CH:72][c:73]1[cH:74][cH:75][cH:76][cH:77][cH:78]1)[CH:79]=[CH:80][c:81]1[cH:82][cH:83][cH:84][cH:85][cH:86]1.[O:87]=[C:88]([CH:89]=[CH:90][c:91]1[cH:92][cH:93][cH:94][cH:95][cH:96]1)[CH:97]=[CH:98][c:99]1[cH:100][cH:101][cH:102][cH:103][cH:104]1.[OH-:35].[OH2:105].[Pd:49].[Pd:50]>>[c:2]1([NH2:27])[cH:3][n:4][c:5]([O:12][CH3:13])[c:6]([C:8](=[O:9])[O:10][CH3:11])[n:7]1Participants
13
Reactant 12
HCID 313Hydrochloric Acid
HCID 923Sodium ion2×
HCID 961Hydroxide
HCID 962Water
HCID 1140Toluene
HCID 6212Chloroform
HCID 8028Tetrahydrofuran
HCID 23938Palladium2×
HCID 95417Dibenzylidene acetone3×
HCID 136809Benzophenone imine
HCID 45749132-Methylpropan-2-olate
HCID 22248028Methyl 6-bromo-3-methoxypyrazine-2-carboxylateProduct 1
Sources & evidence
- ORD record
- ord-1f18c47126ec40348103ddea679ecfb9
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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