Dichloromethane → 3-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]isoxazole-5-carbonitrile
Reaction equation
[Br:1][c:2]1[c:3]([O:4][CH:5]2[CH2:6][CH2:7][N:8]([c:11]3[n:12][o:13][c:14]([C:16](=[O:17])[NH2:18])[cH:15]3)[CH2:9][CH2:10]2)[cH:19][c:20]([F:23])[cH:21][cH:22]1.[CH3:24][CH2:25][N:26]([CH2:27][CH3:28])[CH2:29][CH3:30].[Cl:44][CH2:45][Cl:46].[F:31][C:32]([F:33])([F:34])[C:35]([O:36][C:37](=[O:38])[C:39]([F:40])([F:41])[F:42])=[O:43]>>[Br:1][c:2]1[c:3]([O:4][CH:5]2[CH2:6][CH2:7][N:8]([c:11]3[n:12][o:13][c:14]([C:16]#[N:18])[cH:15]3)[CH2:9][CH2:10]2)[cH:19][c:20]([F:23])[cH:21][cH:22]1Participants
5
Sources & evidence
- ORD record
- ord-a486ef446a8f415b842e4cf57d215232
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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