Dichloromethane → N-(4-ethoxypyrrolidin-3-yl)-3,6-diethylpyrazin-2-amine

HRID 2153779Notes

Reaction equation

HRID 2153779 reaction equation
[CH2:1]([CH3:2])[c:3]1[c:4]([NH:11][CH:12]2[CH2:13][N:14]([C:20]([O:21][CH2:22][c:23]3[cH:24][cH:25][cH:26][cH:27][cH:28]3)=[O:29])[CH2:15][CH:16]2[O:17][CH2:18][CH3:19])[n:5][c:6]([CH2:9][CH3:10])[cH:7][n:8]1.[CH2:30]([N:31]([CH2:32][CH3:33])[CH2:34][CH3:35])[CH3:36].[CH2:37]([SiH:38]([CH2:39][CH3:40])[CH2:41][CH3:42])[CH3:43].[Cl:44][CH2:45][Cl:46].[Pd:47]([Cl:48])[Cl:49]>>[CH2:1]([CH3:2])[c:3]1[c:4]([NH:11][CH:12]2[CH2:13][NH:14][CH2:15][CH:16]2[O:17][CH2:18][CH3:19])[n:5][c:6]([CH2:9][CH3:10])[cH:7][n:8]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 12052TriethylsilaneHCID 24290Palladium ChlorideHCID 23401203Benzyl 3-[(3,6-diethylpyrazin-2-yl)amino]-4-ethoxypyrrolidine-1-carboxylate

Product 1

HCID 22278788N-(4-ethoxypyrrolidin-3-yl)-3,6-diethylpyrazin-2-amine

Sources & evidence

ORD record
ord-7545ca74f36f447c9c4daf2a18fe0af4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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