Tetrahydrofuran → racemic (2'R,3S,4'R)-6-chloro-4'-[5-chloro-2-(2-hydroxy-1,1-dimethyl-ethoxy)-phenyl]-2'-(2,5-difluorophenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione
Reaction equation
[Al+3:43].[CH2:48]1[O:49][CH2:50][CH2:51][CH2:52]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:9]([cH:10]1)[NH:8][C:7](=[O:11])[C:6]21[CH:12]([c:34]2[c:35]([F:41])[cH:36][cH:37][c:38]([F:40])[cH:39]2)[NH:13][C:14](=[O:33])[CH2:15][CH:16]1[c:17]1[c:18]([O:24][C:25]([CH3:26])([CH3:27])[C:28](=[O:29])[O:30][CH2:31][CH3:32])[cH:19][cH:20][c:21]([Cl:23])[cH:22]1.[H-:42].[H-:45].[H-:46].[H-:47].[Li+:44]>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:9]([cH:10]1)[NH:8][C:7](=[O:11])[C:6]21[CH:12]([c:34]2[c:35]([F:41])[cH:36][cH:37][c:38]([F:40])[cH:39]2)[NH:13][C:14](=[O:33])[CH2:15][CH:16]1[c:17]1[c:18]([O:24][C:25]([CH3:26])([CH3:27])[CH2:28][OH:29])[cH:19][cH:20][c:21]([Cl:23])[cH:22]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-31eface006be4c7eb76a6fcb87380ffb
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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