Dimethylformamide → Sorafenib

HRID 2154770Notes

Reaction equation

HRID 2154770 reaction equation
[CH3:45][CH2:46][O:47][C:48](=[O:49])[CH3:50].[CH:40]([N:41]([CH3:42])[CH3:43])=[O:44].[Cl:1][c:2]1[c:3]([C:18]([F:19])([F:20])[F:21])[cH:4][c:5]([NH:8][C:9]([O:10][c:11]2[cH:12][cH:13][cH:14][cH:15][cH:16]2)=[O:17])[cH:6][cH:7]1.[NH2:22][c:23]1[cH:24][cH:25][c:26]([O:27][c:28]2[cH:29][c:30]([C:34](=[O:35])[NH:36][CH3:37])[n:31][cH:32][cH:33]2)[cH:38][cH:39]1>>[Cl:1][c:2]1[c:3]([C:18]([F:19])([F:20])[F:21])[cH:4][c:5]([NH:8][C:9](=[O:17])[NH:22][c:23]2[cH:24][cH:25][c:26]([O:27][c:28]3[cH:29][c:30]([C:34](=[O:35])[NH:36][CH3:37])[n:31][cH:32][cH:33]3)[cH:38][cH:39]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 13412531HCID 13412531, compoundHCID 166551294-(4-Aminophenoxy)-N-methylpicolinamide

Product 1

HCID 216239Sorafenib

Sources & evidence

ORD record
ord-145a6e4fd5294a2f9c036ad2574d5dfb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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