Tetrahydrofuran → 2-Bromo-6-(thiophen-3-yl)pyridine

HRID 2155647Notes

Reaction equation

HRID 2155647 reaction equation
[Br:1][c:2]1[n:3][c:4]([Br:8])[cH:5][cH:6][cH:7]1.[O:17]1[CH2:18][CH2:19][CH2:20][CH2:21]1.[cH:22]1[cH:23][cH:24][c:25]([P:26]([Pd:27]([P:28]([c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)([c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)[c:41]2[cH:42][cH:43][cH:44][cH:45][cH:46]2)([P:47]([c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)([c:54]2[cH:55][cH:56][cH:57][cH:58][cH:59]2)[c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)[P:66]([c:67]2[cH:68][cH:69][cH:70][cH:71][cH:72]2)([c:73]2[cH:74][cH:75][cH:76][cH:77][cH:78]2)[c:79]2[cH:80][cH:81][cH:82][cH:83][cH:84]2)([c:85]2[cH:86][cH:87][cH:88][cH:89][cH:90]2)[c:91]2[cH:92][cH:93][cH:94][cH:95][cH:96]2)[cH:97][cH:98]1.[s:9]1[cH:10][c:11]([B:14]([OH:15])[OH:16])[cH:12][cH:13]1>>[c:2]1(-[c:11]2[cH:10][s:9][cH:13][cH:12]2)[n:3][c:4]([Br:8])[cH:5][cH:6][cH:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 122742,6-DibromopyridineHCID 581760Thiophene-3-boronic acidHCID 178420554HCID 178420554, compound

Product 1

HCID 221807762-Bromo-6-(thiophen-3-yl)pyridine

Sources & evidence

ORD record
ord-b5218576486047979b2e18ef9299cdc8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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