反应详情

To a 0° C. solution of EtMgBr in Et2O (3.0M, 570 mL, Aldrich) was slowly added m-tolunitrile (102 mL, Aldrich). After stirring at r.t. for 19 hr., benzene (300 mL) was added and the resulting mixture was cooled to 0° C. HCl (6N, 600 mL) was then slowly added. The organic phase was separated, washed with 5% NaHCO3 and brine, dried (MgSO4) and evaporated to afford the desired ketone as a yellow liquid.

1. customTo a 0° C.
2. temperaturethe resulting mixture was cooled to 0° C
3. customThe organic phase was separated
4. washwashed with 5% NaHCO3 and brine
5. dry with materialdried (MgSO4)
6. customevaporated