Tetrahydrofuran → [(3RS,4SR)-1-Benzyl-4-(3-chloro-phenyl)-pyrrolidin-3-yl]-(3-fluoro-4-trifluoromethyl-benzyl)-methyl-amine
Reaction equation
[Br:22][CH2:23][c:24]1[cH:25][c:26]([F:34])[c:27]([C:30]([F:31])([F:32])[F:33])[cH:28][cH:29]1.[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]([NH:20][CH3:21])[CH:11]([c:13]2[cH:14][c:15]([Cl:19])[cH:16][cH:17][cH:18]2)[CH2:12]1.[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[CH3:35][CH2:36][N:37]([CH2:38][CH3:39])[CH2:40][CH3:41]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]([N:20]([CH3:21])[CH2:23][c:24]2[cH:25][c:26]([F:34])[c:27]([C:30]([F:31])([F:32])[F:33])[cH:28][cH:29]2)[CH:11]([c:13]2[cH:14][c:15]([Cl:19])[cH:16][cH:17][cH:18]2)[CH2:12]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-18128d4a8a514132b37e4f086f3268df
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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