Acetate → 5-[3,5-Bis(trifluoromethyl)phenyl]-3-[[4-fluoro-2-(4-fluoro-2-methoxy-5-propan-2-ylphenyl)phenyl]methyl]-4-methyl-1,3-oxazolidin-2-one

HRID 2156682Notes

Reaction equation

HRID 2156682 reaction equation
[C:48]([P:49]([C:50]([CH3:51])([CH3:52])[CH3:53])[C:54]([CH3:55])([CH3:56])[CH3:57])([CH3:58])([CH3:59])[CH3:60].[CH2:63]1[O:64][CH2:65][CH2:66][O:67][CH2:68]1.[CH3:78][CH2:79][CH2:80][CH2:81][CH2:82][CH3:83].[F:1][C:2]([c:3]1[cH:4][c:5]([CH:13]2[CH:14]([CH3:28])[N:15]([CH2:19][c:20]3[c:21]([Cl:27])[cH:22][c:23]([F:26])[cH:24][cH:25]3)[C:16](=[O:18])[O:17]2)[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1)([F:29])[F:30].[F:31][c:32]1[cH:33][c:34]([O:44][CH3:45])[c:35]([B:41]([OH:42])[OH:43])[cH:36][c:37]1[CH:38]([CH3:39])[CH3:40].[K+:47].[N:61]#[N:62].[O-:70][C:71]([CH3:72])=[O:73].[O-:74][C:75]([CH3:76])=[O:77].[OH-:46].[Pd+2:69]>>[F:1][C:2]([c:3]1[cH:4][c:5]([CH:13]2[CH:14]([CH3:28])[N:15]([CH2:19][c:20]3[c:21](-[c:35]4[c:34]([O:44][CH3:45])[cH:33][c:32]([F:31])[c:37]([CH:38]([CH3:39])[CH3:40])[cH:36]4)[cH:22][c:23]([F:26])[cH:24][cH:25]3)[C:16](=[O:18])[O:17]2)[cH:6][c:7]([C:9]([F:10])([F:11])[F:12])[cH:8]1)([F:29])[F:30]

Participants

11

Reactant 10

HCID 175Acetate2×HCID 813Potassium CationHCID 947NitrogenHCID 961HydroxideHCID 8058HexaneHCID 312751,4-DioxaneHCID 83681Tris(1,1-dimethylethyl)phosphineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 53363739(4-Fluoro-5-isopropyl-2-methoxyphenyl)boronic acidHCID 725259865-[3,5-Bis(trifluoromethyl)phenyl]-3-[(2-chloro-4-fluorophenyl)methyl]-4-methyl-1,3-oxazolidin-2-one

Product 1

HCID 730273445-[3,5-Bis(trifluoromethyl)phenyl]-3-[[4-fluoro-2-(4-fluoro-2-methoxy-5-propan-2-ylphenyl)phenyl]methyl]-4-methyl-1,3-oxazolidin-2-one

Sources & evidence

ORD record
ord-11cce467a823472fa1a5cd9daba4e339
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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