Dimethylformamide → tert-Butyl 4-(4-isopropylthiazole-2-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

HRID 2156847Notes

Reaction equation

HRID 2156847 reaction equation
[CH3:54][CH2:55][N:56]([CH2:57][CH3:58])[CH2:59][CH3:60].[CH:25]([CH3:26])([CH3:27])[c:28]1[n:29][c:30]([C:33](=[O:34])[OH:35])[s:31][cH:32]1.[O:36]1[CH2:37][CH2:38][NH:39][CH2:40][C:41]12[CH2:42][CH2:43][N:44]([C:47](=[O:48])[O:49][C:50]([CH3:51])([CH3:52])[CH3:53])[CH2:45][CH2:46]2.[O:61]=[CH:62][N:63]([CH3:64])[CH3:65].[P-:1]([F:2])([F:3])([F:4])([F:5])([F:6])[F:7].[n:8]1([O:9][C:10]([N:11]([CH3:12])[CH3:13])=[N+:14]([CH3:15])[CH3:16])[c:17]2[n:18][cH:19][cH:20][cH:21][c:22]2[n:23][n:24]1>>[CH:25]([CH3:26])([CH3:27])[c:28]1[n:29][c:30]([C:33](=[O:35])[N:39]2[CH2:38][CH2:37][O:36][C:41]3([CH2:40]2)[CH2:42][CH2:43][N:44]([C:47](=[O:48])[O:49][C:50]([CH3:51])([CH3:52])[CH3:53])[CH2:45][CH2:46]3)[s:31][cH:32]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 9886HexafluorophosphateHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 224993072-Thiazolecarboxylic acid, 4-(1-methylethyl)-HCID 53302318tert-Butyl 1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

Product 1

HCID 57988958tert-Butyl 4-(4-isopropylthiazole-2-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecane-9-carboxylate

Sources & evidence

ORD record
ord-56a15129e48642dd898c70b52d82c7a1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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