Tetrahydrofuran → Diethyl (7,8-difluoro-3-methyl-3,4-dihydro-2H-[1,4]benzoxazine-4-yl)methylenemalonate
Reaction equation
[F:32][c:33]1[c:34]([O:53][CH2:54][CH:55]([CH3:56])[OH:57])[c:35]([NH:40][CH:41]=[C:42]([C:43](=[O:44])[O:45][CH2:46][CH3:47])[C:48](=[O:49])[O:50][CH2:51][CH3:52])[cH:36][cH:37][c:38]1[F:39].[O:20]=[C:21]([O:22][CH2:23][CH3:24])[N:25]=[N:26][C:27]([O:28][CH2:29][CH3:30])=[O:31].[O:58]1[CH2:59][CH2:60][CH2:61][CH2:62]1.[c:1]1([P:2]([c:3]2[cH:4][cH:5][cH:6][cH:7][cH:8]2)[c:9]2[cH:10][cH:11][cH:12][cH:13][cH:14]2)[cH:15][cH:16][cH:17][cH:18][cH:19]1>>[F:32][c:33]1[c:34]2[c:35]([cH:36][cH:37][c:38]1[F:39])[N:40]([CH:41]=[C:42]([C:43](=[O:44])[O:45][CH2:46][CH3:47])[C:48](=[O:49])[O:50][CH2:51][CH3:52])[CH:55]([CH3:56])[CH2:54][O:53]2Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-802eb26b6d37496d8c4c253f63bf7010
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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