Dimethylformamide → Tert-butyl (3rs,4rs)-3-naphthalen-2-ylmethoxy-4-[4-(2-[1,2,4]triazol-1-yl-ethoxy)-phenyl]-piperidine-1-carboxylate

HRID 2157197Notes

Reaction equation

HRID 2157197 reaction equation
[CH3:1][S:2]([O:3][CH2:6][CH2:7][O:8][c:9]1[cH:10][cH:11][c:12]([CH:15]2[CH:16]([O:28][CH2:29][c:30]3[cH:31][c:32]4[cH:33][cH:34][cH:35][cH:36][c:37]4[cH:38][cH:39]3)[CH2:17][N:18]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:19][CH2:20]2)[cH:13][cH:14]1)(=[O:4])=[O:5].[CH3:46][N:47]([CH3:48])[CH:49]=[O:50].[Na:40].[nH:41]1[n:42][cH:43][n:44][cH:45]1>>[CH2:6]([CH2:7][O:8][c:9]1[cH:10][cH:11][c:12]([CH:15]2[CH:16]([O:28][CH2:29][c:30]3[cH:31][c:32]4[cH:33][cH:34][cH:35][cH:36][c:37]4[cH:38][cH:39]3)[CH2:17][N:18]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:19][CH2:20]2)[cH:13][cH:14]1)[n:41]1[n:42][cH:43][n:44][cH:45]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 92571H-1,2,4-TriazoleHCID 5360545SodiumHCID 86604409tert-butyl (3RS,4RS)-4-[4-(2-methylsulfonyloxy-ethoxy)-phenyl]-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate

Product 1

HCID 53745200Tert-butyl (3rs,4rs)-3-naphthalen-2-ylmethoxy-4-[4-(2-[1,2,4]triazol-1-yl-ethoxy)-phenyl]-piperidine-1-carboxylate

Sources & evidence

ORD record
ord-62174cbe3cca4e37b05672a483bb5290
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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