Dimethylformamide → Tert-butyl 3-[[6-fluoro-1-(4-methoxybutyl)benzimidazole-2-carbonyl]-(2-methylpropyl)amino]-5-(morpholine-4-carbonyl)piperidine-1-carboxylate

HRID 2157246Notes

Reaction equation

HRID 2157246 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([C:37](=[O:38])[OH:39])[CH2:11][CH:12]([N:14]([CH2:15][CH:16]([CH3:17])[CH3:18])[C:19](=[O:20])[c:21]2[n:22][c:23]3[c:24]([n:25]2[CH2:26][CH2:27][CH2:28][CH2:29][O:30][CH3:31])[cH:32][c:33]([F:36])[cH:34][cH:35]3)[CH2:13]1.[CH2:50]1[CH2:51][O:52][CH2:53][CH2:54][NH:55]1.[CH:56]([N:57]([CH:58]([CH3:59])[CH3:60])[CH2:61][CH3:62])([CH3:63])[CH3:64].[O:65]=[CH:66][N:67]([CH3:68])[CH3:69].[OH:40][n:41]1[c:42]2[c:43]([cH:44][cH:45][cH:46][cH:47]2)[n:48][n:49]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([C:37](=[O:39])[N:55]2[CH2:50][CH2:51][O:52][CH2:53][CH2:54]2)[CH2:11][CH:12]([N:14]([CH2:15][CH:16]([CH3:17])[CH3:18])[C:19](=[O:20])[c:21]2[n:22][c:23]3[c:24]([n:25]2[CH2:26][CH2:27][CH2:28][CH2:29][O:30][CH3:31])[cH:32][c:33]([F:36])[cH:34][cH:35]3)[CH2:13]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 8083MorpholineHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 70872690HCID 70872690, compound

Product 1

HCID 76731340Tert-butyl 3-[[6-fluoro-1-(4-methoxybutyl)benzimidazole-2-carbonyl]-(2-methylpropyl)amino]-5-(morpholine-4-carbonyl)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-fc6357146c1e4cd890acfd5f69abef4d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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