反应详情

A mixture of 7-carbomethoxy-4-phenylcoumarin (510 mg), 1N LiOH (10 mL), THF (7 mL) and MeOH (10 mL) was heated at reflux for 1 hr. The solution was concentrated then H2O (10 mL), 1N HCl (15 mL), THF (10 mL) and Et2O (10 mL) were added and stirring continued for 1 hr. After this time, the organic layer was separated and concentrated to yield the title compound which was used as such in the next step.

1. temperaturewas heated
2. temperatureat reflux for 1 hr
3. concentrationThe solution was concentrated
4. additionH2O (10 mL), 1N HCl (15 mL), THF (10 mL) and Et2O (10 mL) were added
5. customAfter this time, the organic layer was separated
6. concentrationconcentrated