HCID 67022971, compound → HCID 67023020, compound

HRID 215890Notes

Reaction equation

HRID 215890 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]#[C:16][C:17]2[N:25]=[C:24]3[C:20]([N:21]=[CH:22][N:23]3[C@@H:26]3[CH2:30][C@H:29]([NH:31][C:32](=[O:35])[CH2:33][OH:34])[C@@H:28]([OH:36])[C@H:27]3[OH:37])=[C:19]([NH:38][C@H:39]([CH2:47][OH:48])[CH2:40][C:41]3[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=3)[N:18]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.CO>[OH:36][C@H:28]1[C@@H:27]([OH:37])[C@H:26]([N:23]2[CH:22]=[N:21][C:20]3[C:24]2=[N:25][C:17]([C:16]#[C:15][CH2:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[N:18][C:19]=3[NH:38][C@H:39]([CH2:47][OH:48])[CH2:40][C:41]2[CH:42]=[CH:43][CH:44]=[CH:45][CH:46]=2)[CH2:30][C@@H:29]1[NH:31][C:32](=[O:35])[CH2:33][OH:34]

Participants

4

Reactant 1

HCID 67022971HCID 67022971, compound

Product 1

HCID 67023020HCID 67023020, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

4-{3-[9-[(1R,2S,3R,4S)-2,3-Dihydroxy-4-(2-hydroxy-acetylamino)-cyclopentyl]-6-((S)-1-hydroxymethyl-2-phenyl-ethylamino)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid tert-butyl ester (Intermediate XB) is dissolved in 1.25 M HCl in MeOH. After stirring at RT for 3 days, the solvent is removed in vacuo to yield the title compound. This is used in the next step without further purification.

Workup

  1. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-0d95a04e131e4ae0a5c89f3c8d55844d
Source dataset
uspto-grants-2012_06
Patent number
US08193164B2

Reaction notes

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