Trifluoroacetic acid → HCID 58006125, compound

HRID 215917Notes

Reaction equation

HRID 215917 reaction equation
[CH3:1][N:2]([CH3:43])[C:3]1[CH:40]=[CH:39][CH:38]=[C:37]([O:41][CH3:42])[C:4]=1[CH2:5][N:6]1[CH2:11][CH2:10][CH:9]([NH:12][C:13]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:16]=[C:15]([NH:23][CH2:24][CH2:25][CH2:26][CH2:27][N:28](C)[C:29](=O)OC(C)(C)C)[N:14]=2)[CH2:8][CH2:7]1.FC(F)(F)C(O)=O>ClCCl>[CH3:43][N:2]([CH3:1])[C:3]1[CH:40]=[CH:39][CH:38]=[C:37]([O:41][CH3:42])[C:4]=1[CH2:5][N:6]1[CH2:7][CH2:8][CH:9]([NH:12][C:13]2[C:22]3[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=3)[N:16]=[C:15]([NH:23][CH2:24][CH2:25][CH2:26][CH2:27][NH:28][CH3:29])[N:14]=2)[CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 58006162HCID 58006162, compound

Product 1

HCID 58006125HCID 58006125, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A solution of Compound 101 (39 mg, 0.07 mmol) and trifluoroacetic acid (0.2 ml, 0.35 mmol) in dichloromethane (3 mL) was stirred at room temperature for 2 h. The product (Compound 102) was purified by basic alumina flash column chromatography using 3% MeOH and 97% CH2Cl2 solution as eluent.

Workup

  1. customThe product (Compound 102) was purified by basic alumina flash column chromatography

Sources & evidence

ORD record
ord-1bc9de4b677d460da4086d9041e88904
Source dataset
uspto-grants-2012_06
Patent number
US08193203B2

Reaction notes

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