反应详情

A solution of 1H-indole-7-carbaldehyde (500 mg, 3.444 mmol) and dimethylsulfate (478 mg, 3.789 mmol) in DMF (3 ml) was cannulated into a suspension of NaH (99 mg, 95% in mineral oil, 4.133 mmol) in DMF (2 ml) at 0° C. The reaction was stirred and allowed to warmed up to room temperature for 1 hour. The reaction was quenched with water and the product was extracted with EtOAC (×2). The organic layers were combined and washed with water, and brine, and dried (MgSO4) and the solution was concentrated to produce a light pink solid, which was used in the next step without further purification.

1. customThe reaction was quenched with water
2. extractionthe product was extracted with EtOAC (×2)
3. washwashed with water, and brine
4. dry with materialdried (MgSO4)
5. concentrationthe solution was concentrated
6. customto produce a light pink solid, which
7. customwas used in the next step without further purification