Tetrahydrofuran → tert-butyl 4-{2-[3-(3,4-difluorophenyl)-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]ethyl}piperazine-1-carboxylate

HRID 2159250Notes

Reaction equation

HRID 2159250 reaction equation
[F:1][c:2]1[cH:3][c:4]([N:9]2[S:10](=[O:18])(=[O:19])[NH:11][c:12]3[c:13]2[cH:14][cH:15][cH:16][cH:17]3)[cH:5][cH:6][c:7]1[F:8].[O:55]1[CH2:56][CH2:57][CH2:58][CH2:59]1.[OH:39][CH2:40][CH2:41][N:42]1[CH2:43][CH2:44][N:45]([C:48](=[O:49])[O:50][C:51]([CH3:52])([CH3:53])[CH3:54])[CH2:46][CH2:47]1.[c:20]1([P:21]([c:22]2[cH:23][cH:24][cH:25][cH:26][cH:27]2)[c:28]2[cH:29][cH:30][cH:31][cH:32][cH:33]2)[cH:34][cH:35][cH:36][cH:37][cH:38]1>>[F:1][c:2]1[cH:3][c:4]([N:9]2[S:10](=[O:18])(=[O:19])[N:11]([CH2:40][CH2:41][N:42]3[CH2:43][CH2:44][N:45]([C:48](=[O:49])[O:50][C:51]([CH3:52])([CH3:53])[CH3:54])[CH2:46][CH2:47]3)[c:12]3[c:13]2[cH:14][cH:15][cH:16][cH:17]3)[cH:5][cH:6][c:7]1[F:8]

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 735736Tert-butyl 4-(2-hydroxyethyl)piperazine-1-carboxylateHCID 468333821-(3,4-Difluorophenyl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide

Product 1

HCID 68709692tert-butyl 4-{2-[3-(3,4-difluorophenyl)-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]ethyl}piperazine-1-carboxylate

Sources & evidence

ORD record
ord-79c7b333c93f4635be142730c7a8b93d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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