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HRID215951

反应详情

EQUATION

反应方程式

HRID 215951 的结构方程式

REACTANTS

反应物

3
结构：N#Cc1ccc(F)cc1
HCID14517

4-Fluorobenzonitrile

C7H4FN

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：O=C1N([C@H]2CC[C@H](O)CC2)CCC12CCNCC2
HCID178517869

未命名化合物

PRODUCTS

生成物

1
结构：N#Cc1ccc(N2CCC3(CC2)CCN([C@H]2CC[C@H](O)CC2)C3=O)cc1
HCID178509997

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CO
溶剂HCID887

Methanol

CH4O

结构：CN1CCCC1=O
溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

PROCEDURE

实验过程

A mixture of 2-(trans-4-hydroxycyclohexyl)-2,8-diazaspiro[4.5]decan-1-one (20 mg, 0.00008 mol), 4-fluorobenzonitrile (12.3 mg, 0.000102 mol) and N,N-diisopropylethylamine (44 μL, 0.00025 mol) in N-methylpyrrolidinone (0.5 mL) was irradiated under microwave at 200° C. for 15 min. The mixture was diluted with methanol (1.3 mL), and purified by Prep-HPLC to give 4-[2-(trans-4-hydroxycyclohexyl)-1-oxo-2,8-diazaspiro[4.5]dec-8-yl]benzonitrile. LCMS: (M+H)+=354.2.

WORKUP

后处理

  1. customwas irradiated under microwave at 200° C. for 15 min
  2. custompurified by Prep-HPLC