反应详情

A mixture of 2-(cis-4-hydroxycyclohexyl)-2,8-diazaspiro[4.5]decan-1-one (20 mg, 0.08 mmol), 4-fluorobenzonitrile (12.3 mg, 0.102 mmol) and N,N-diisopropylethylamine (44 μL, 0.25 mmol) in N-methylpyrrolidinone (0.5 mL) was irradiated under microwave at 200° C. for 15 min. The mixture was diluted with methanol (1.3 mL), and purified by Prep-HPLC to give 8-(3-fluoropyridin-2-yl)-2-(cis-4-hydroxycyclohexyl)-2,8-diazaspiro[4.5]decan-1-one. LCMS: (M+H)+=348.2.

1. customwas irradiated under microwave at 200° C. for 15 min
2. custompurified by Prep-HPLC