Ammonia → 3',4'-Dihydro-2'H-spiro[1,3-dioxane-2,10'-pyrimido[1,2-a]indol]-8'-amine

HRID 2159652Notes

Reaction equation

HRID 2159652 reaction equation
[CH2:21]1[O:22][CH2:23][CH2:24][CH2:25]1.[CH3:26][CH2:27][O:28][C:29]([CH3:30])=[O:31].[NH2:1][c:2]1[cH:3][c:4]2[c:5]([cH:6][cH:7]1)[N:8]([CH2:17][CH2:18][CH2:19][NH2:20])[C:9](=[O:16])[C:10]21[O:11][CH2:12][CH2:13][CH2:14][O:15]1.[NH3:32]>>[NH2:1][c:2]1[cH:3][c:4]2[c:5]([cH:6][cH:7]1)[N:8]1[C:9](=[N:20][CH2:19][CH2:18][CH2:17]1)[C:10]21[O:11][CH2:12][CH2:13][CH2:14][O:15]1

Participants

5

Reactant 4

HCID 222AmmoniaHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 589325815'-Amino-1'-(3-aminopropyl)spiro[1,3-dioxane-2,3'-indol]-2'(1'H)-one

Product 1

HCID 116804673',4'-Dihydro-2'H-spiro[1,3-dioxane-2,10'-pyrimido[1,2-a]indol]-8'-amine

Sources & evidence

ORD record
ord-be900f46e01e43aa958602aa56b6039c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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