反应详情

温度

80 °C

1-(tert-butoxycarbonyl)-4-methylpiperidine-4-carboxylic acid (243 mg, 1.0 mmol), 3-(4-fluorophenoxy)aniline (203 mg, 1.0 mmol), DCC (206 mg, 1.0 mmol), and HOAt (138 mg, 1.01 mmol) were combined in EtOAc (50 mL) and DMF (5 mL). The reaction mixture was heated at 80° C. for 20 hours. Most of the EtOAc was evaporated, resulting in precipitation of a solid, which was removed by filtration. The filtrate was diluted with EtOAc, washed with 1 N aq. HCl, water, and brine, dried, and concentrated under vacuum to give the title compound. MS (ES+) [M+H]+=429.

1. customMost of the EtOAc was evaporated
2. customresulting in precipitation of a solid, which
3. customwas removed by filtration
4. additionThe filtrate was diluted with EtOAc
5. washwashed with 1 N aq. HCl, water, and brine
6. customdried
7. concentrationconcentrated under vacuum