Acetate → N-Trifluoroacetyl-7-methoxy-1-methylene 2,3,4,5-tetrahydro-1H-3-benzazepine

HRID 2160279Notes

Reaction equation

HRID 2160279 reaction equation
[CH2:1]([CH:2]=[CH2:3])[N:4]([C:5]([C:6]([F:7])([F:8])[F:9])=[O:10])[CH2:11][CH2:12][c:13]1[c:14]([I:21])[cH:15][cH:16][c:17]([O:19][CH3:20])[cH:18]1.[CH3:46][N:47]([CH3:48])[CH:49]=[O:50].[K+:26].[O-:22][C:23]([CH3:24])=[O:25].[O-:52][C:53]([CH3:54])=[O:55].[O-:56][C:57]([CH3:58])=[O:59].[Pd+2:51].[c:27]1([P:28]([c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[c:35]2[cH:36][cH:37][cH:38][cH:39][cH:40]2)[cH:41][cH:42][cH:43][cH:44][cH:45]1>>[CH2:1]1[C:2](=[CH2:3])[c:14]2[c:13]([cH:18][c:17]([O:19][CH3:20])[cH:16][cH:15]2)[CH2:12][CH2:11][N:4]1[C:5]([C:6]([F:7])([F:8])[F:9])=[O:10]

Participants

7

Reactant 6

HCID 175Acetate3×HCID 813Potassium CationHCID 6228DimethylformamideHCID 11776TriphenylphosphineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 86760840HCID 86760840, compound

Product 1

HCID 22292788N-Trifluoroacetyl-7-methoxy-1-methylene 2,3,4,5-tetrahydro-1H-3-benzazepine

Sources & evidence

ORD record
ord-bd0cecfd820e4770affbc72e17d506fb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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