Bicarbonate Ion → 5-[2,6-Difluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(1H-pyrazol-5-yl)pyridazin-3-yl]amino}thiophene-3-carboxamide
Reaction equation
[C:37](=[O:38])([OH:39])[O-:40].[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]([NH:8][c:9]2[s:10][c:11](-[c:17]3[c:18]([F:28])[cH:19][c:20]([C:24]([CH3:25])([CH3:26])[OH:27])[cH:21][c:22]3[F:23])[cH:12][c:13]2[C:14](=[O:15])[NH2:16])[n:6][n:7]1.[Na+:41].[nH:29]1[n:30][c:31]([B:34]([OH:35])[OH:36])[cH:32][cH:33]1>>[c:2]1(-[c:31]2[nH:30][n:29][cH:33][cH:32]2)[cH:3][cH:4][c:5]([NH:8][c:9]2[s:10][c:11](-[c:17]3[c:18]([F:28])[cH:19][c:20]([C:24]([CH3:25])([CH3:26])[OH:27])[cH:21][c:22]3[F:23])[cH:12][c:13]2[C:14](=[O:15])[NH2:16])[n:6][n:7]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-b426b8a5b2d7494aa57d43dd13a32690
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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