1-Butanol → 4-Amino-5-cyclobutyloxy-6,7-dimethoxy-2-[4-(4-morpholinecarbonyl)-1,4-diazepan-1-yl]quinazoline
Reaction equation
[CH2:45]([OH:46])[CH2:47][CH2:48][CH3:49].[CH3:38][CH2:39][N:40]([CH2:41][CH3:42])[CH2:43][CH3:44].[ClH:22].[NH2:1][c:2]1[n:3][c:4]([Cl:21])[n:5][c:6]2[cH:7][c:8]([O:19][CH3:20])[c:9]([O:17][CH3:18])[c:10]([O:12][CH:13]3[CH2:14][CH2:15][CH2:16]3)[c:11]12.[O:23]1[CH2:24][CH2:25][N:26]([C:29](=[O:30])[N:31]2[CH2:32][CH2:33][NH:34][CH2:35][CH2:36][CH2:37]2)[CH2:27][CH2:28]1>>[NH2:1][c:2]1[n:3][c:4]([N:34]2[CH2:33][CH2:32][N:31]([C:29]([N:26]3[CH2:25][CH2:24][O:23][CH2:28][CH2:27]3)=[O:30])[CH2:37][CH2:36][CH2:35]2)[n:5][c:6]2[cH:7][c:8]([O:19][CH3:20])[c:9]([O:17][CH3:18])[c:10]([O:12][CH:13]3[CH2:14][CH2:15][CH2:16]3)[c:11]12Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-38cd33d7601d4ab58a0fbb9174b29595
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (4/10)
Reaction notes
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