Tetrahydrofuran → 1-(4-Chlorophenyl)-1-(2-fluoro-3-(4-fluoro-3-phenoxyphenyl)prop-1-enyl)cyclopropane

HRID 2161264Notes

Reaction equation

HRID 2161264 reaction equation
[C:17]([O:18][CH2:21][C:22](=[CH:23][C:24]1([c:27]2[cH:28][cH:29][c:30]([Cl:33])[cH:31][cH:32]2)[CH2:25][CH2:26]1)[F:34])(=[O:19])[CH3:20].[F:1][c:2]1[c:3]([O:9][c:10]2[cH:11][cH:12][cH:13][cH:14][cH:15]2)[cH:4][c:5]([Br:8])[cH:6][cH:7]1.[Mg:16].[O:35]1[CH2:36][CH2:37][CH2:38][CH2:39]1>>[F:1][c:2]1[c:3]([O:9][c:10]2[cH:11][cH:12][cH:13][cH:14][cH:15]2)[cH:4][c:5]([CH2:21][C:22](=[CH:23][C:24]2([c:27]3[cH:28][cH:29][c:30]([Cl:33])[cH:31][cH:32]3)[CH2:25][CH2:26]2)[F:34])[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 5462224MagnesiumHCID 11076399Benzene, 4-bromo-1-fluoro-2-phenoxy-HCID 543111381-(3-Acetoxy-2-fluoroprop-1-enyl)-1-(4-chlorophenyl)cyclopropane

Product 1

HCID 211854051-(4-Chlorophenyl)-1-(2-fluoro-3-(4-fluoro-3-phenoxyphenyl)prop-1-enyl)cyclopropane

Sources & evidence

ORD record
ord-dc28d711b00f4648b14c7443aac3b353
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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