1,1-Dimethoxyethyl(dimethyl)amine → HCID 58990371, compound

HRID 216145Notes

Reaction equation

HRID 216145 reaction equation
[CH3:1][O:2][C:3]1[N:8]=[C:7]([C:9]2[CH:10]=[C:11]([CH:15]=[CH:16][CH:17]=2)[C:12]([NH2:14])=[O:13])[CH:6]=[C:5]([NH:18][CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=2)[N:4]=1.CO[C:31](OC)([N:33]([CH3:35])[CH3:34])[CH3:32]>>[CH3:34][N:33]([CH3:35])[C:31](=[N:14][C:12](=[O:13])[C:11]1[CH:15]=[CH:16][CH:17]=[C:9]([C:7]2[CH:6]=[C:5]([NH:18][CH2:19][CH2:20][C:21]3[CH:22]=[CH:23][C:24]([O:27][CH3:28])=[CH:25][CH:26]=3)[N:4]=[C:3]([O:2][CH3:1])[N:8]=2)[CH:10]=1)[CH3:32]

Participants

3

Reactant 2

HCID 878351,1-Dimethoxyethyl(dimethyl)amineHCID 11552604HCID 11552604, compound

Product 1

HCID 58990371HCID 58990371, compound

Conditions

Temperature
110 °C

Procedure

A mixture of 3-{2-methoxy-6-[2-(4-methoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-benzamide [50 mg, 0.132 mmol, Example 35(g)] and dimethylacetamide dimethylacetal (2 mL) in a sealed tube and heated to 110° C. for 45 minutes. The mixture is concentrated by rotary evaporator to provide N-(1-dimethylamino-ethylidene)-3-{2-methoxy-6-[2-(4-methoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-benzamide [Intermediate (46)] in quantitative yield.

Workup

  1. concentrationThe mixture is concentrated by rotary evaporator

Sources & evidence

ORD record
ord-a2a17cdfb00e48fe803d4a0c211d98fe
Source dataset
uspto-grants-2012_06
Patent number
US08193183B2

Reaction notes

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