Tetrahydrofuran → Ethyl 3-[4-({2',6'-dimethyl-4'-[(6-methylpyridin-2-yl)methoxy]biphenyl-3-yl}methoxy)-2-fluorophenyl]propanoate

HRID 2161617Notes

Reaction equation

HRID 2161617 reaction equation
[CH3:32][c:33]1[cH:34][cH:35][cH:36][c:37]([CH2:39][OH:40])[n:38]1.[F:1][c:2]1[c:3]([CH2:25][CH2:26][C:27](=[O:28])[O:29][CH2:30][CH3:31])[cH:4][cH:5][c:6]([O:8][CH2:9][c:10]2[cH:11][c:12](-[c:16]3[c:17]([CH3:24])[cH:18][c:19]([OH:23])[cH:20][c:21]3[CH3:22])[cH:13][cH:14][cH:15]2)[cH:7]1.[O:60]=[C:61]([O:62][CH:63]([CH3:64])[CH3:65])[N:66]=[N:67][C:68]([O:69][CH:70]([CH3:71])[CH3:72])=[O:73].[O:74]1[CH2:75][CH2:76][CH2:77][CH2:78]1.[c:41]1([P:42]([c:43]2[cH:44][cH:45][cH:46][cH:47][cH:48]2)[c:49]2[cH:50][cH:51][cH:52][cH:53][cH:54]2)[cH:55][cH:56][cH:57][cH:58][cH:59]1>>[F:1][c:2]1[c:3]([CH2:25][CH2:26][C:27](=[O:28])[O:29][CH2:30][CH3:31])[cH:4][cH:5][c:6]([O:8][CH2:9][c:10]2[cH:11][c:12](-[c:16]3[c:17]([CH3:24])[cH:18][c:19]([O:23][CH2:39][c:37]4[cH:36][cH:35][cH:34][c:33]([CH3:32])[n:38]4)[cH:20][c:21]3[CH3:22])[cH:13][cH:14][cH:15]2)[cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 11776TriphenylphosphineHCID 707366-Methyl-2-pyridylmethanolHCID 75555Diisopropyl diazene-1,2-dicarboxylateHCID 58903128Ethyl 3-{2-fluoro-4-[(4'-hydroxy-2',6'-dimethylbiphenyl-3-yl)methoxy]phenyl}propanoate

Product 1

HCID 58903176Ethyl 3-[4-({2',6'-dimethyl-4'-[(6-methylpyridin-2-yl)methoxy]biphenyl-3-yl}methoxy)-2-fluorophenyl]propanoate

Sources & evidence

ORD record
ord-3079cc0bfcd94076822fe3ad57d65b5d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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