Benzaldehyde → Thiophene-2-carboxylic acid (3-benzyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-fluoro-4-morpholin-4-yl-phenyl)-amide

HRID 2161951Notes

Reaction equation

HRID 2161951 reaction equation
[CH:36](=[O:37])[c:38]1[cH:39][cH:40][cH:41][cH:42][cH:43]1.[CH:8]12[CH2:9][NH:10][CH2:11][CH:12]1[CH:13]2[CH2:14][N:15]([C:16](=[O:17])[c:18]1[s:19][cH:20][cH:21][cH:22]1)[c:23]1[cH:24][c:25]([F:35])[c:26]([N:29]2[CH2:30][CH2:31][O:32][CH2:33][CH2:34]2)[cH:27][cH:28]1.[Cl:44][CH2:45][Cl:46].[F:1][C:2]([F:3])([F:4])[C:5]([OH:6])=[O:7]>>[CH:8]12[CH2:9][N:10]([CH2:36][c:38]3[cH:39][cH:40][cH:41][cH:42][cH:43]3)[CH2:11][CH:12]1[CH:13]2[CH2:14][N:15]([C:16](=[O:17])[c:18]1[s:19][cH:20][cH:21][cH:22]1)[c:23]1[cH:24][c:25]([F:35])[c:26]([N:29]2[CH2:30][CH2:31][O:32][CH2:33][CH2:34]2)[cH:27][cH:28]1

Participants

5

Reactant 4

HCID 240BenzaldehydeHCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 72401275Thiophene-2-carboxylic acid (3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-fluoro-4-morpholin-4-yl-phenyl)-amide

Product 1

HCID 86597826Thiophene-2-carboxylic acid (3-benzyl-3-aza-bicyclo[3.1.0]hex-6-ylmethyl)-(3-fluoro-4-morpholin-4-yl-phenyl)-amide

Sources & evidence

ORD record
ord-166c06a19bc8433fb2461aded7391090
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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