Dimethylformamide → 5-(4-chloro-3-(2-phenylpropan-2-ylcarbamoyl)phenyl)-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

HRID 2162509Notes

Reaction equation

HRID 2162509 reaction equation
[C:31]([CH3:32])([CH3:33])([c:34]1[cH:35][cH:36][cH:37][cH:38][cH:39]1)[NH2:40].[CH:41]([N:42]([CH2:43][CH3:44])[CH:45]([CH3:46])[CH3:47])([CH3:48])[CH3:49].[Cl:1][c:2]1[c:3]([C:4](=[O:5])[OH:6])[cH:7][c:8](-[c:11]2[cH:12][cH:13][c:14]3[c:15]([c:16]([C:26]([NH:27][CH3:28])=[O:29])[c:17](-[c:19]4[cH:20][cH:21][c:22]([F:25])[cH:23][cH:24]4)[o:18]3)[cH:30]2)[cH:9][cH:10]1.[O:74]=[CH:75][N:76]([CH3:77])[CH3:78].[P-:50]([F:51])([F:52])([F:53])([F:54])([F:55])[F:56].[n:57]1([O:58][C:59]([N:60]([CH3:61])[CH3:62])=[N+:63]([CH3:64])[CH3:65])[c:66]2[n:67][cH:68][cH:69][cH:70][c:71]2[n:72][n:73]1>>[Cl:1][c:2]1[c:3]([C:4](=[O:5])[NH:40][C:31]([CH3:32])([CH3:33])[c:34]2[cH:35][cH:36][cH:37][cH:38][cH:39]2)[cH:7][c:8](-[c:11]2[cH:12][cH:13][c:14]3[c:15]([c:16]([C:26]([NH:27][CH3:28])=[O:29])[c:17](-[c:19]4[cH:20][cH:21][c:22]([F:25])[cH:23][cH:24]4)[o:18]3)[cH:30]2)[cH:9][cH:10]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 68509CumylamineHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 592751302-Chloro-5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl)benzoic acid

Product 1

HCID 592753255-(4-chloro-3-(2-phenylpropan-2-ylcarbamoyl)phenyl)-2-(4-fluorophenyl)-N-methylbenzofuran-3-carboxamide

Sources & evidence

ORD record
ord-a224d479c3294948bb1b15236d6d3587
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (4/10)

Reaction notes

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