反应详情

温度

25 °C

A solution of the product of Example 148D (0.19 g) in N,N-dimethylformamide (3.5 mL) was treated with diethylamine (0.35 mL), stirred at 25° C. for 1.5 hours and concentrated. A solution of the residue in dichloroethane (7 mL) was treated with bis-(p-nitrophenyl) carbonate (0.128 g, 1.2 equivalents), stirred at 60° C. for 16 hours and concentrated. The residue was chromatographed on silica gel, eluting with ethyl acetate:dichloromethane (3:2) to give 80 mg (64%) of the title compound.

1. concentrationconcentrated
2. stirringstirred at 60° C. for 16 hours
3. concentrationconcentrated
4. customThe residue was chromatographed on silica gel
5. washeluting with ethyl acetate:dichloromethane (3:2)