Acetyl chloride → HCID 22754116, compound

HRID 2163153Notes

Reaction equation

HRID 2163153 reaction equation
[NH2:1][C:2]1[C:3]([I:21])=[C:4]([C:13]([NH:15][C:16]([CH3:20])([CH3:19])[CH2:17][OH:18])=[O:14])[C:5]([I:12])=[C:6]([C:10]=1[I:11])[C:7]([OH:9])=[O:8].[C:22](Cl)(=[O:24])[CH3:23]>CC(N(C)C)=O>[C:22]([NH:1][C:2]1[C:3]([I:21])=[C:4]([C:13]([NH:15][C:16]([CH3:19])([CH3:20])[CH2:17][OH:18])=[O:14])[C:5]([I:12])=[C:6]([C:10]=1[I:11])[C:7]([OH:9])=[O:8])(=[O:24])[CH3:23]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 22754101HCID 22754101, compound

Product 1

HCID 22754116HCID 22754116, compound

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

Analogously to Example 3, 63.0 g. (100 mmol) of 5-amino-N-(2-hydroxy-1,1-dimethylethyl)-2,4,6-triiodoisophthalamic acid is reacted in 120 ml. of dimethylacetamide with 17 ml. of acetyl chloride and worked up. Yield: 64.0 g. (95%), m.p. 279°-281° C., with decomposition.

Sources & evidence

ORD record
ord-09d9d98d66034d95826c634901d17133
Source dataset
uspto-grants-1979_01
Patent number
US04132731

Reaction notes

Loading…