Hydrochloric Acid → HCID 22751875, compound

HRID 2163437Notes

Reaction equation

HRID 2163437 reaction equation
[CH:1]([N:4]([CH:28]([CH3:30])[CH3:29])[CH2:5][CH2:6][C:7]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)([CH2:11][CH2:12][N:13]1[CH2:19][CH:18]2[CH2:20][CH2:21][CH:15]([CH2:16][CH2:17]2)[CH2:14]1)[C:8]([NH2:10])=[O:9])([CH3:3])[CH3:2].CCOCC.[ClH:36]>C(O)(C)C>[ClH:36].[ClH:36].[CH:28]([N:4]([CH:1]([CH3:3])[CH3:2])[CH2:5][CH2:6][C:7]([C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1)([CH2:11][CH2:12][N:13]1[CH2:14][CH:15]2[CH2:16][CH2:17][CH:18]([CH2:20][CH2:21]2)[CH2:19]1)[C:8]([NH2:10])=[O:9])([CH3:30])[CH3:29]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 12612295HCID 12612295, compound

Product 1

HCID 22751875HCID 22751875, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

To a solution of 10 parts of 2-[2-(diisopropylamino)ethyl]-2-phenyl-4-(3-azabicyclo[3.2.2]non-3-yl)butyramide in 350 parts by volume of ether is added dropwise with stirring 2 molar equivalents of hydrochloric acid in isopropyl alcohol. The mixture is stirred for about 2 hours when the resulting salt is separated by filtration to afford 2-[2-(diisopropylamino)ethyl]-2-phenyl-4-(3-azabicyclo[3.2.2]non-3-yl)butyramide dihydrochloride.

Workup

  1. customis separated by filtration

Sources & evidence

ORD record
ord-c3e9f630d6c54c32a0ffc07c98fcd51f
Source dataset
uspto-grants-1979_01
Patent number
US04134890

Reaction notes

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