反应详情

Piperidine (2.1 g., 0.0237mole) and 2-cyanoacetamide (22.0g., 0.263 mole) are added to a slurry of 6-nitroveratraldehyde (50.0 g., 0.237 mole) in methanol (500 ml.). The mixture is heated to reflux for two hours, and then cooled in an ice bath and filtered. The bright yellow filter cake is washed with cold isopropanol (300 ml.) and then air dried. Yield = 60.1 g. (93%); m.p. 265°-266° C.

1. temperatureThe mixture is heated
2. temperatureto reflux for two hours
3. temperaturecooled in an ice bath
4. filtrationfiltered
5. washThe bright yellow filter cake is washed with cold isopropanol (300 ml.)
6. customair dried