Piperazine → 1,4-Bis(chloroacetyl)piperazine

HRID 2163796Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[Cl:7][CH2:8][C:9](Cl)=[O:10]>>[Cl:7][CH2:8][C:9]([N:1]1[CH2:6][CH2:5][N:4]([C:9](=[O:10])[CH2:8][Cl:7])[CH2:3][CH2:2]1)=[O:10]

Participants

Reactant 2

HCID 4837Piperazine

HCID 6577Chloroacetyl chloride

Product 1

HCID 2375751,4-Bis(chloroacetyl)piperazine

Procedure

By reacting 8.6 g of piperazine with 23 g of chloroacetic chloride in the same manner as described in Synthesis Example 1, 36 g of crystals of the title compound were obtained.

Sources & evidence

ORD record: ord-37bf63610eff42939a8e27499376e4fd
Source dataset: uspto-grants-1979_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04137082

Reaction notes

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