反应详情

A mixture of dry dimethylformamide (150 ml) and potassium carbonate (12.0 g) is stirred and methyl mercaptan is introduced as a gas for 45 minutes. After stirring for another 45 minutes, 3-chloro-4-nitroaniline (10.0 g) is added. The mixture is stirred and heated at 120°-130° C. for 18 hours. It is then cooled and poured into water (1 liter), the precipitate is collected and recrystallized from methanol to afford 8 grams of 3-methylthio-4-nitroaniline, m.p. 178°-182° C.

1. stirringAfter stirring for another 45 minutes
2. stirringThe mixture is stirred
3. temperatureheated at 120°-130° C. for 18 hours
4. temperatureIt is then cooled
5. customthe precipitate is collected
6. customrecrystallized from methanol