3'-Aminoacetophenone → HCID 2555322, compound

HRID 2164053Notes

Reaction equation

HRID 2164053 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7](Cl)=[O:8])[CH:3]=1.[NH2:10][C:11]1[CH:12]=[C:13]([C:17](=[O:19])[CH3:18])[CH:14]=[CH:15][CH:16]=1.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O.O>[C:17]([C:13]1[CH:12]=[C:11]([CH:16]=[CH:15][CH:14]=1)[NH:10][C:7]([C:4]1[CH:3]=[C:2]([CH3:1])[O:6][N:5]=1)=[O:8])(=[O:19])[CH3:18]

Participants

6

Reactant 3

HCID 74173'-AminoacetophenoneHCID 11430Potassium CarbonateHCID 27368945-Methylisoxazole-3-carbonyl chloride

Product 1

HCID 2555322HCID 2555322, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolvent2×HCID 962WaterSolvent

Procedure

A solution of 5-methyl-3-isoxazolecarbonyl chloride (14.5 g) in acetone (30 ml) was added to a solution of m-aminoacetophenone (13.8 g) in acetone (280 ml) in the presence of anhydrous potassium carbonate (21.0 g). The mixture was stirred for 1/2hour, and then diluted with water. The precipitated product was filtered, washed with water and dried. Yield = 20.5 g (83%), m.p. 188°-190°.

Workup

  1. filtrationThe precipitated product was filtered
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-d98adba4e0404f57b20cf63f0058ff24
Source dataset
uspto-grants-1979_01
Patent number
US04137321

Reaction notes

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