Dichloromethane → HCID 22750291, compound

HRID 2164163Notes

Reaction equation

HRID 2164163 reaction equation
[N:1]1([S:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[NH:16][C:17](=[O:24])[C:18](=[CH:22][CH:23]=3)[C:19](O)=O)=[CH:11][CH:10]=2)(=[O:8])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.C(Cl)[Cl:26].C[Si](Cl)(C)C.S(Cl)(Cl)=O>C(N(CC)CC)C>[N:1]1([S:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]3[NH:16][C:17](=[O:24])[C:18](=[CH:22][CH:23]=3)[CH2:19][Cl:26])=[CH:11][CH:10]=2)(=[O:8])=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 6397ChlorotrimethylsilaneHCID 24386Thionyl ChlorideHCID 22750311HCID 22750311, compound

Product 1

HCID 22750291HCID 22750291, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

From 4.4 g. of 6-[4-(1-pyrrolidinylsulfonyl)phenyl]-1,2-dihydro-2-oxonicotinic acid in 150 ml. of methylene chloride, 1.6 ml. of triethylamine, 1.45 ml. of trimethylsilyl chloride and 1.7 ml. of thionyl chloride, following the procedure of a) above, there is obtained 6-[4-(1-pyrrolidinylsulfonyl)phenyl]-1,2-dihydro-2-oxonicotinyl chloride.

Sources & evidence

ORD record
ord-33dd4b6e3b084da18d4e85c6e0517c42
Source dataset
uspto-grants-1979_01
Patent number
US04137408

Reaction notes

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