Water → HCID 53884408, compound

HRID 2164308Notes

Reaction equation

HRID 2164308 reaction equation
O.[NH2:2][C:3]1[C:8]([C:9](=[S:17])[C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=2)=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:18][C:19]([OH:21])=[O:20].[Na].[CH2:23](I)[CH3:24].O>CN(C)C=O>[NH2:2][C:3]1[C:8]([C:9](=[S:17])[C:10]2[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=2)=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:18][C:19]([O:21][CH2:23][CH3:24])=[O:20]

Participants

5

Reactant 3

HCID 962WaterHCID 6340IodoethaneHCID 86739958HCID 86739958, compound

Product 1

HCID 53884408HCID 53884408, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Seventeen grams (0.05 mole) of sodium 2-amino-3-(4-methylthiobenzoyl)phenylacetic acid monohydrate are dissolved in approximately 150 ml of dimethylformamide and the solution treated with 33 g ethyl iodide. The solution is stirred at room temperature for 2.5 hrs. and added to water and the mixture extracted several times with benzene. The combined benzene extracts are washed with dilute base and water, dried over sodium sulfate and concentrated to obtain the titled compound.

Workup

  1. extractionthe mixture extracted several times with benzene
  2. washThe combined benzene extracts are washed
  3. additionwith dilute base and water
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-bb5f931244ca44d18ef9084d3daba63c
Source dataset
uspto-grants-1985_03
Patent number
US04503073

Reaction notes

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