Hydrazine hydrate (1:1) → HCID 13116742, compound

HRID 2164396Notes

Reaction equation

HRID 2164396 reaction equation
[N:1]1([CH2:6][CH2:7][C:8]2[S:12][C:11]([C:13](=O)[CH2:14][CH2:15][C:16]([OH:18])=O)=[CH:10][CH:9]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.O.[NH2:21][NH2:22]>O>[N:1]1([CH2:6][CH2:7][C:8]2[S:12][C:11]([C:13]3[CH2:14][CH2:15][C:16](=[O:18])[NH:21][N:22]=3)=[CH:10][CH:9]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 13120582HCID 13120582, compound

Product 1

HCID 13116742HCID 13116742, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
90 °C

Procedure

4.2 g of 4-{5-[2-(1-imidazolyl)-ethyl]-thien-2-yl}-4-oxo-butyric acid are suspended in 10 ml of water, 0.8 g of hydrazine hydrate are added and the mixture is stirred at 90° C. for 2 hours. After the mixture has been cooled, it is extracted with chloroform. The chloroform phase is washed with water, dried over Na2SO4 and concentrated to dryness.

Workup

  1. temperatureAfter the mixture has been cooled
  2. extractionit is extracted with chloroform
  3. washThe chloroform phase is washed with water
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-6f5143f4115943d5a1f1a10a8f8fd129
Source dataset
uspto-grants-1985_03
Patent number
US04504479

Reaction notes

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