反应详情

12.5 g of 5-(3-trifluoromethylphenylsulfonyloxy)-2-ureidoaniline, 13.6 g of N,N'-bismethoxycarbonyl-S-methylisothiourea and 100 mg of p-toluenesulfonic acid in 90 ml of ethyl acetate and 45 ml of methanol are stirred under reflux for 20 minutes. After cooling down, the mixture is evaporated to dryness under reduced pressure, and the residue is stirred with diisopropyl ether and filtered off with suction. Recrystallization from ethyl acetate/diisopropyl ether, melting point 131° C.

1. temperatureunder reflux for 20 minutes
2. temperatureAfter cooling down
3. customthe mixture is evaporated to dryness under reduced pressure
4. filtrationfiltered off with suction
5. customRecrystallization from ethyl acetate/diisopropyl ether, melting point 131° C.