Water → HCID 13476999, compound

HRID 2164502Notes

Reaction equation

HRID 2164502 reaction equation
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]([CH3:10])([CH3:9])[CH3:8])[NH:4][N:3]=1.C(N(CC)CC)C.[CH:18]1([C:21](Cl)=[O:22])[CH2:20][CH2:19]1.O>C(Cl)Cl.C(Cl)(Cl)(Cl)Cl>[C:7]([C:5]1[NH:4][N:3]=[C:2]([NH:1][C:21]([CH:18]2[CH2:20][CH2:19]2)=[O:22])[CH:6]=1)([CH3:10])([CH3:9])[CH3:8]

Participants

7

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 77637Cyclopropanecarbonyl chlorideHCID 5227873-Amino-5-tert-butylpyrazole

Product 1

HCID 13476999HCID 13476999, compoundYield 51.1%

Reagents, catalysts & solvents 2

HCID 5943Carbon TetrachlorideSolventHCID 6344DichloromethaneSolvent

Procedure

7 g (0.05 mole) of 3-amino-5-t-butylpyrazole as prepared in Example 1 and 6 g of triethylamine were dissolved in 50 ml of methylene chloride. To this solution was added dropwise 5.7 g of cyclopropanecarboxylic acid chloride dissolved in 50 ml of carbon tetrachloride. The resulting mixture was allowed to stand over night. Thereafter, water was added thereto whereby crystals were precipitated. The crystals were collected by filtration and washed with water and carbon tetrachloride to obtain 5.3 g of 5-t-butyl-3-cyclopropanecarbonylaminopyrazole.

Workup

  1. waitto stand over night
  2. customwhereby crystals were precipitated
  3. filtrationThe crystals were collected by filtration
  4. washwashed with water and carbon tetrachloride

Sources & evidence

ORD record
ord-e9c72bcc82994fb1afad43e98ccb593f
Source dataset
uspto-grants-1985_03
Patent number
US04505739

Reaction notes

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