Triethylamine → HCID 77975665, compound

HRID 2164564Notes

Reaction equation

HRID 2164564 reaction equation
[ClH:1].[CH3:2][O:3][C:4](=[O:8])[CH:5]([CH3:7])[NH2:6].C(N(CC)CC)C.[CH2:16]([O:19][C:20]1[CH:25]=[CH:24][C:23]([CH2:26][C:27](O)=[O:28])=[CH:22][C:21]=1Cl)[CH:17]=[CH2:18].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)Cl>[CH3:2][O:3][C:4](=[O:8])[CH:5]([CH2:7][Cl:1])[NH:6][C:27](=[O:28])[CH2:26][C:23]1[CH:22]=[CH:21][C:20]([O:19][CH2:16][CH:17]=[CH2:18])=[CH:25][CH:24]=1

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 10868DicyclohexylcarbodiimideHCID 30951AlclofenacHCID 2756298Alanine, methyl ester, hydrochloride (1:1)

Product 1

HCID 77975665HCID 77975665, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A suspension of (DL)-alanine methyl ester hydrochloride (2.8 g) in dry methylene chloride (10 ml) containing dry triethylamine (2.8 ml) was added to a solution of 4-allyloxy-3-chloro-phenylacetic acid (4.3 g) in dry methylene chloride (30 ml). N,N'-dicyclohexyl-carbodiimide (DCC; 4.1 g) was added and the reaction mixture was stirred at room temperature.

Sources & evidence

ORD record
ord-ad3754857c324bae8e35e6484816bc0e
Source dataset
uspto-grants-1985_03
Patent number
US04505898

Reaction notes

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