Water → HCID 13389076, compound

HRID 2164760Notes

Reaction equation

HRID 2164760 reaction equation
[NH2:1][C:2]1[C:7]([CH:8]=O)=[N:6][C:5]([Cl:10])=[C:4]([Cl:11])[N:3]=1.[CH2:12]([NH2:15])[CH2:13]C.O.[CH:17](O)(C)C>>[Cl:10][C:5]1[N:6]=[C:7]([CH:8]=[N:15][CH:12]([CH3:13])[CH3:17])[C:2]([NH2:1])=[N:3][C:4]=1[Cl:11]

Participants

5

Reactant 4

HCID 962WaterHCID 3776IsopropanolHCID 7852PropylamineHCID 133678713-Amino-5,6-dichloropyrazine-2-carbaldehyde

Product 1

HCID 13389076HCID 13389076, compound

Procedure

In 1.2 ml of isopropyl alcohol there was dissolved 2-amino-5,6-dichloro-3-formylpyrazine (0.095 g; 0.0005M) prepared in Step B, after which n-propylamine (32 mg; 0.042 ml; 0.00055M) was added, and the reaction mixture was stirred at room temperature for 20.5 hours. When water was added to the reaction mixture, product precipitated, was filtered, and dried (23 mg). Additional product precipitated, was filtered, and dried (46 mg). The product was recrystallized from ethyl acetate/hexane. Elemental Analysis for C8H10N4Cl2.

Workup

  1. customprepared in Step B
  2. customprecipitated
  3. filtrationwas filtered
  4. customdried (23 mg)
  5. customAdditional product precipitated
  6. filtrationwas filtered
  7. customdried (46 mg)
  8. customThe product was recrystallized from ethyl acetate/hexane

Sources & evidence

ORD record
ord-c7ec4bdcb250423bbbd3d8110005170f
Source dataset
uspto-grants-1985_03
Patent number
US04507299

Reaction notes

Loading…